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Invitrogen™ KIF2A Polyclonal Antibody
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Catalog No. PA1640
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200 μL
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PA1640 200 μL
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Catalog No. PA1640 Supplier Invitrogen™ Supplier No. PA1640
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Description

Rabbit Polyclonal Antibody

PA1-640 detects kinesin 2 (KIF2) from mouse tissues. PA1-640 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~95 kDa protein representing KIF2 from mouse brain homogenate. PA1-640 immunizing peptide corresonds to amino acid residues 1-11 from mouse KIF2. This sequence is completely conserved in human KIF2. PA1-640 immunizing peptide (Cat. # PEP-040) is available for use in neutralization and control experiments.

KIF2A, a gene encoding the kinesin family member 2A protein, plays a pivotal role in neuronal development and function. This gene is part of the kinesin-13 subfamily, characterized by its unique ability to depolymerize microtubules, which are essential components of the cytoskeleton responsible for maintaining cell shape, enabling motility, and facilitating intracellular transport. KIF2A is particularly significant in neural settings, where it regulates microtubule dynamics crucial for neuronal migration and dendritic development. Dysfunctional KIF2A, due to mutations, has been linked to early-onset neurodegenerative diseases such as progressive microcephaly and mental disabilities due to impaired microtubule regulation, reflecting its foundational role in correct brain development and architecture. Additionally, KIF2A is involved in spindle assembly and chromosome segregation during cell division, further cementing its importance in both neurodevelopment and general cellular functions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KIF2A
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Kif2a
Gene Accession No. P28740
Gene Alias C530030B14Rik; CDCBM3; HK2; hypothetical protein; KIF2; kif2a; kif2-a; kif2a {ECO:0000250; kif2a.L; kinesin family member 2A; kinesin heavy chain family, member 2; kinesin heavy chain member 2; kinesin heavy chain member 2A; kinesin heavy chain member 2A L homeolog; Kinesin, heavy chain, 2; kinesin-2; Kinesin-like protein KIF2A; kinesin-related protein XKIF2; Kns2; M-kinesin; RCJMB04_9a7; UniProtKB:O00139}; Unknown (protein for MGC:133806); XELAEV_18008243mg
Gene Symbols Kif2a
Host Species Rabbit
Immunogen Synthetic Peptide: M(1) V T S L N E D N E S(11) C.
Purification Method Antigen affinity chromatography
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16563
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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