Invitrogen™ KIF3A Polyclonal Antibody

Catalog No.	Quantity
PIPA5121019	100 μL

Catalog No. PIPA5121019 Supplier Invitrogen™ Supplier No. PA5121019

Description

Rabbit Polyclonal Antibody

Positive test controls include: MCF-7, SW480, 293T, SKOV3, HeLa, Mouse brain, Mouse ovary, Rat liver, Rat brain. The target is usually found in the following locations: Cell projection, Cytoplasm, cilium, cytoskeleton. Immunogen sequence: RKALETKLDM EEEERNKARA ELEKREKDLL KAQQEHQSLL EKLSALEKKV IVGGVDLLAK AEEQEKLLEE SNMELEERRK RAEQLRRELE EKEQERLDIE EKYTSLQEEA QGKTKKLKKV WTMLMAAKSE MADLQQEHQR EIEGLLENIR QLSRELRLQM LIIDNFIPRD YQEMIENYVH WNEDIGEWQL KCVAYTGNNM RKQTPVPDKK EKDPFEVDLS HVYLAYTEES LRQSLMKLER PRTSKGKARP KTGRRKRSAK PETVIDSLLQ.

The kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. Members of the heterotrimeric kinesin II family of microtubule associated motors generally contain two different motor subunits from the KIF3 family, which includes KIF3A, B and C. KIF3 isoforms mediate anterograde transport of membrane bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis. KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined. Loss of KIF3A function in mice photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.

Specifications

• Antigen: KIF3A
• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 2.38 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: KIF3A
• Gene Accession No.: P28741, Q9Y496
• Gene Alias: fc55h04; FLA10; hypothetical protein LOC550267; Kif3; KIF3A; Kifl; kinesin family member 3a; kinesin family protein 3A; kinesin-II subunit; kinesin-like protein KIF3A; Kinesin-like protein KIF3A-like protein; KLP-20; Kns3; microtubule plus end-directed kinesin motor 3A; N-4 kinesin; Unknown (protein for IMAGE:7984856); wu:fc55h04; zgc:110284; zgc:110284 protein
• Gene Symbols: KIF3A
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 430-699 of human KIF3A (NP_008985.3).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11127, 16568, 84392
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG