Kindlin 2 Monoclonal Antibody (OTI14A11), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA524938

Catalog No. PIMA524938

Description

Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. [UniProt]

Specifications

• Antigen: Kindlin 2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8CIB5, Q96AC1
• Gene Symbols: FERMT2
• Immunogen: Full-length protein expressed in 293T cell transfected with human FERMT2 expression vector
• Quantity: 100μL
• Primary or Secondary: Primary
• Target Species: Canine, Human, Mouse, Non-human Primate, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: OTI14A11
• Conjugate: Unconjugated
• Gene: FERMT2
• Gene Alias: AA960555; EGK_18193; Fermitin family homolog 2; fermitin family homolog 2 (Drosophila); fermitin family member 2; fermt2; im:7145859; im:7145859 protein; KIND2; kindlin 2; kindlin-2; LOC616981 protein; MIG2; mig-2; mitogen inducible 2; mitogen inducible gene 2 protein; mitogen-inducible gene 2 protein; PH domain-containing family C member 1; pleckstrin homology domain containing, family C (with FERM domain) member 1; pleckstrin homology domain containing, family C member 1; pleckstrin homology domain-containing family C member 1; Plekhc1; UNC112; UNC112B
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10979, 218952, 289992, 490693
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid