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Invitrogen™ Kindlin 2 Monoclonal Antibody (OTI14A11)
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Catalog No. PIMA524938
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100 μL
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PIMA524938 100 μL
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Catalog No. PIMA524938 Supplier Invitrogen™ Supplier No. MA524938
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Description

Mouse Monoclonal Antibody

Kindlin 2 Monoclonal Antibody for ICC/IF, IHC (P), IP, Western Blot

Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kindlin 2
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone OTI14A11
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 1% BSA and 0.02% sodium azide; pH 7.3
Gene FERMT2
Gene Accession No. Q8CIB5, Q96AC1
Gene Alias AA960555; EGK_18193; Fermitin family homolog 2; fermitin family homolog 2 (Drosophila); fermitin family member 2; fermt2; im:7145859; im:7145859 protein; KIND2; kindlin 2; kindlin-2; LOC616981 protein; MIG2; mig-2; mitogen inducible 2; mitogen inducible gene 2 protein; mitogen-inducible gene 2 protein; PH domain-containing family C member 1; pleckstrin homology domain containing, family C (with FERM domain) member 1; pleckstrin homology domain containing, family C member 1; pleckstrin homology domain-containing family C member 1; Plekhc1; UNC112; UNC112B
Gene Symbols FERMT2
Host Species Mouse
Immunogen Full-length protein expressed in 293T cell transfected with human FERMT2 expression vector.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10979, 218952, 289992, 490693
Target Species Human, Mouse, Rat, Canine, Monkey
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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