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Invitrogen™ Kindlin Polyclonal Antibody
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Catalog No. PIPA519817
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100 μg
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Catalog No. Quantity
PIPA519817 100 μg
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Catalog No. PIPA519817 Supplier Invitrogen™ Supplier No. PA519817
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Description

Rabbit Polyclonal Antibody

Heat mediated antigen retrieval recommended prior to tissue staining. This antibody is predicted to react with cow and Xenopus laevis based on sequence homology.

Kindlin 1 is a member of the kindlin family of focal adhesion proteins and contains a FERM domain and pleckstrin homology domain. It is involved in integrin signaling, linkage of the cytoskeleton to the extracellular matrix, and cell adhesion. It is most often expressed in epithelial cells. When kindlin 1 is coexpressed with talin it helps to activate ITGA2B. It is required for keratinocyte proliferation, polarization of basal keratinocytes in the skin, and for normal cell shape. Mutations in kindlin 1 have been linked to Kindler syndrome, a recessive skin disorder involving blistering, photosensitivity, poikiloderma, and atrophy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kindlin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.02% sodium azide; pH 7.4
Gene FERMT1
Gene Accession No. P59113, Q9BQL6
Gene Alias 5830467P10Rik; C20orf42; DTGCU2; Fermitin family homolog 1; fermitin family homolog 1 (Drosophila); fermitin family member 1; FERMT1; FLJ20116; FLJ23423; KIND1; Kindlerin; kindlin 1; kindlin syndrome protein; Kindlin-1; RGD1306816; RP5-1056H1.1; UNC112 related protein 1; UNC-112 related protein 1; UNC112A; unc-112-related protein 1; URP1
Gene Symbols FERMT1
Host Species Rabbit
Immunogen Synthetic peptide conjugated to KLH derived from within residues 650 to the C-terminus of Human Kindlin.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 241639, 55612
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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