Invitrogen™ Kininogen 1 Monoclonal Antibody (288422)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA523988

Catalog No. PIMA523988

Description

In Western blots, reacts with the full length mouse Kininogen (aa 21-661), but not with the light chain alone. In Western blots, no cross-reactivity with recombinant human (rh) Cystatin D, F, SA, SN, recombinant mouse (rm) Cystatin A, B, C, E/M, rmCystatin/Stefin Homolog, rmFetuin A, rhFetuin B, rmHPRG, rhKininogen, or rhKininostatin is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Kininogen 1
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O08677
• Gene Symbols: KNG1
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Kininogen Glu21-Ser661.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunoprecipitation, Western Blot
• Clone: 288422
• Conjugate: Unconjugated
• Gene: KNG1
• Gene Alias: alpha-1-MAP; Alpha-2-thiol proteinase inhibitor; BDK; BK; Bradykinin; fitzgerald factor; high molecular weight kininogen; H-kininigen; HMWK; Ile-Ser-Bradykinin; Kallidin I; Kallidin II; kininogen; kininogen 1; kininogen 1-like 1; kininogen-1; Kininogen-1 heavy chain; Kininogen-1 light chain; Kng; Kng1; Kng1l1; L-kininogen; low molecular weight (LMW) T-kininogen II; Low molecular weight growth-promoting factor; Lysyl-bradykinin; Major acute phase protein; major acute phase protein (alpha-1-MAP); Thiostatin; T-kinin; T-kininogen 2; T-kininogen 2 heavy chain; T-kininogen 2 light chain; T-kininogen II; T-kininogen II heavy chain; T-kininogen II light chain; williams-Fitzgerald-Flaujeac factor
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 16644
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized