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Invitrogen™ Kininogen Light Chain Monoclonal Antibody (288424)
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Catalog No. PIMA523989
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100 μg
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Catalog No. Quantity
PIMA523989 100 μg
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Catalog No. PIMA523989 Supplier Invitrogen™ Supplier No. MA523989
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Description

Rat Monoclonal Antibody

In Western blots, reacts with full length Kininogen (aa 21-661) and several forms of the light chain starting at residue 389, and does not react with the heavy chain. In Western blots, no cross-reactivity with recombinant mouse (rm) Cystatin A, B, C, E/M, recombinant human (rh) Cystatin D, F, S, SA, SN, rmCystatin/Stefin Homolog, rmFetuin A, rhFetuin B, rmHPRG, rhKininogen, or rhKininostatin is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kininogen Light Chain
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 288424
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene KNG1
Gene Accession No. O08677
Gene Alias alpha-1-MAP; Alpha-2-thiol proteinase inhibitor; BDK; BK; bradykinin; Fitzgerald factor; high molecular weight kininogen; H-kininigen; HMWK; Ile-Ser-Bradykinin; Kallidin I; Kallidin II; kininogen; kininogen 1; kininogen 1-like 1; kininogen-1; Kininogen-1 heavy chain; Kininogen-1 light chain; KNG; KNG1; Kng1l1; L-kininogen; low molecular weight (LMW) T-kininogen II; Low molecular weight growth-promoting factor; Lysyl-bradykinin; Major acute phase protein; major acute phase protein (alpha-1-MAP); Thiostatin; T-kinin; T-kininogen 2; T-kininogen 2 heavy chain; T-kininogen 2 light chain; T-kininogen II; T-kininogen II heavy chain; T-kininogen II light chain; williams-Fitzgerald-Flaujeac factor
Gene Symbols KNG1
Host Species Rat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse Kininogen Glu21-Ser661.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16644
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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