Invitrogen™ Kir1.1 (KCNJ1) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA541070

Catalog No. PIPA541070

Description

Peptide sequence: LRKSLLIGSH IYGKLLKTTV TPEGETIILD QININFVVDA GNENLFFISP Sequence homology: Cow: 86%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Kir1.1 (KCNJ1)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNJ1
• Gene Alias: ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; inward rectifier K(+) channel Kir1.1; inwardly rectifying K+ channel; inwardly rectifying potassium channel ROMK-2; K+ channel protein; KAB-1; Kcnj; Kcnj1; KIR1.1; LOW QUALITY PROTEIN: ATP-sensitive inward rectifier potassium channel 1; OTTHUMP00000045938; potassium channel, inwardly rectifying subfamily J member 1; potassium channel, inwardly rectifying subfamily J, member 1; potassium inwardly rectifying channel subfamily J member 1; potassium inwardly-rectifying channel J1; Potassium inwardly-rectifying channel subfamily J; potassium inwardly-rectifying channel, subfamily J, member 1; potassium voltage-gated channel subfamily J member 1; ROMK; ROMK1; Romk2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3758, 56379
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: O88335, P48048
• Gene Symbols: KCNJ1
• Immunogen: Synthetic peptide directed towards the middle region of human KCNJ1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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