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Invitrogen™ Kir2.2 (KCNJ12) Polyclonal Antibody
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Catalog No. PIPA555485
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100 μL
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PIPA555485 100 μL
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Catalog No. PIPA555485 Supplier Invitrogen™ Supplier No. PA555485
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RCSAKDLVEN KFLLPSANSF CYENELAFLS RDEEDEADGD QDGRSRDGLS PQARHDFDRL QAGGGVLEQR PYRRESEI Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 81%.

Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kir2.2 (KCNJ12)
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Kcnj12
Gene Accession No. Q14500
Gene Alias ATP-sensitive inward rectifier potassium channel 12; atrium potassium channel IRK; DirK; hIRK; hIRK1; hkir2.2x; Inward rectifier K(+) channel Kir2.2; inward rectifier K(+) channel Kir2.2v; inward rectifier K(+) channel Kir2.6; inward rectifier potassium channel Kir2.2; inwardly-rectifying potassium channel KCNJ12; inwardly-rectifying potassium channel Kir2.2; IRK; Irk2; IRK-2; KCNJ12; kcnj12x; KCNJN1; Kir2.1; Kir2.2; Kir2.2v; MB-IRK2; potassium channel, inwardly rectifying subfamily J member 12; potassium channel, inwardly rectifying subfamily J, member 12; potassium inwardly rectifying channel subfamily J member 12; potassium inwardly-rectifying channel J12; potassium inwardly-rectifying channel, subfamily J, inhibitor 1; potassium inwardly-rectifying channel, subfamily J, member 12; potassium voltage-gated channel subfamily J member 12; subfamily J, member 12
Gene Symbols Kcnj12
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human KCNJ12. Recombinant protein control fragment (Product #RP-91128).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3768
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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