Invitrogen™ KIR2DL3 Polyclonal Antibody

Catalog No.	Quantity
PIPA595861	100 μL

Catalog No. PIPA595861 Supplier Invitrogen™ Supplier No. PA595861

Description

Rabbit Polyclonal Antibody

Immunogen sequence: HEGVHRKPSL LAHPGPLVKS EETVILQCWS DVRFQHFLLH REGKFKDTLH LIGEHHDGVS KANFSIGPMM QDLAGTYRCY GSVTHSPYQL SAPSDPLDIV ITGLYEKPSL SAQPGPTVLA GESVTLSCSS RSSYDMYHLS REGEAHERRF SAGPKVNGTF QADFPLGPAT HGGTYRCFGS FRDSPYEWSN SSDPLLVSVT GNPSNSWPSP TEPSSETGNP RHLH; Positive Samples: HepG2, Mouse liver, Mouse kidney, Mouse heart; Cellular Location: Cell membrane, Single-pass type I membrane protein.

NKAT (NK-associated transcripts) gene products, known as killer immuno-globulin-like receptors or KIRs, downregulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. This family of receptors is characterized by an extracellular region with two to three immunoglobulin-superfamily domains and a cytoplasmic domain with an antigen receptor activation motif (ARAM). KIRs and other inhibitory receptors also possess a common cytoplasmic sequence (I/VxYxxL/V) known as an ITIM (immunoreceptor tyrosine-based inhibitory motif). The human inhibitory human killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3), also referred to as CD158b, is an inhibitory receptor that is specific for the human MHC class I molecule HLA-Cw3 and related alleles.

Specifications

• Antigen: KIR2DL3
• Applications: ELISA, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1.55 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: KIR2DL3
• Gene Accession No.: P43628
• Gene Alias: CD158 antigen-like family member B2; CD158b; CD158B2; CU464054.1; GL183; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3; killer cell immunoglobulin-like receptor 2DL3; killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 3; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 3; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5; killer Ig-like inhibitory receptor; killer inhibitory receptor cl 2-3; KIR-023GB; KIR2DL3; KIR2DS3; KIR2DS5; KIRCL23; KIR-K7b; KIR-K7c; MGC129943; MHC class I NK cell receptor; natural killer associated transcript 2; natural killer cell inhibitory receptor KIR2DL3; natural killer cell receptor; natural killer-associated transcript 2; NKAT; NKAT2; NKAT-2; NKAT2A; NKAT2B; NK-receptor; p58; p58 natural killer cell receptor clone CL-6; p58 NK receptor CL-6; p58.2 MHC class-I specific NK receptor; p58.2 MHC class-I-specific NK receptor
• Gene Symbols: KIR2DL3
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-245 of human KIR2DL3 (NP_0569522).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3804
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG