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Invitrogen™ KIR2DL4 Monoclonal Antibody (mAb#33)
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Catalog No. PIMA110110
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100 μg
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Catalog No. Quantity
PIMA110110 100 μg
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Catalog No. PIMA110110 Supplier Invitrogen™ Supplier No. MA110110
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Description

Mouse Monoclonal Antibody

This antibody recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.

CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KIR2DL4
Applications Flow Cytometry, Immunoprecipitation, Immunocytochemistry, Western Blot
Classification Monoclonal
Clone mAb#33
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene KIR2DL4
Gene Accession No. Q99706
Gene Alias CD158 antigen-like family member D; CD158D; G9P; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4; killer cell immunoglobulin-like receptor 2DL4; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4; killer cell inhibitory receptor 103AS; killer Ig receptor; killer-cell immunoglobulin-like receptor; killer-cell immunoglobulin-like receptor 2DL4; KIR; KIR103; KIR103AS; KIR-103AS; KIR2DL4; KIR-2DL4; MHC class I NK cell receptor KIR103AS; natural killer cell inhibitory receptor; natural killer cell receptor; NK cell receptor
Gene Symbols KIR2DL4
Host Species Mouse
Immunogen NK3.3 cells and KIR2DL4-Ig fusion protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3805
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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