Invitrogen™ KIR2DL4 Monoclonal Antibody (mAb#33), APC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA528573

Catalog No. PIMA528573

Description

This antibody recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals. Recommended dilution is for 100 μL of whole blood or 1x10^6 cells in suspension.

CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.

Specifications

• Antigen: KIR2DL4
• Classification: Monoclonal
• Conjugate: APC
• Gene: KIR2DL4
• Gene Alias: CD158 antigen-like family member D; CD158D; G9P; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4; killer cell immunoglobulin-like receptor 2DL4; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4; killer cell inhibitory receptor 103AS; killer Ig receptor; killer-cell immunoglobulin-like receptor; killer-cell immunoglobulin-like receptor 2DL4; KIR; KIR103; KIR103AS; KIR-103AS; KIR2DL4; KIR-2DL4; MHC class I NK cell receptor KIR103AS; natural killer cell inhibitory receptor; natural killer cell receptor; NK cell receptor
• Host Species: Mouse
• Purification Method: Size-exclusion chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3805
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: mAb#33
• Formulation: PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
• Gene Accession No.: Q99706
• Gene Symbols: KIR2DL4
• Immunogen: NK3.3 cells and KIR2DL4-Ig fusion protein.
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ