KIR2DL4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA588793

Catalog No. PIPA588793

Description

Immunogen sequence: WAHVGGQDKP FCSAWPSAVV PQGGHVTLRC HYRRGFNIFT LYKKDGVPVP ELYNRIFWNS FLISPVTPAH AGTYRCRGFH PHSPTEWSAP SNPLVIMVTG LYEKPSLTAR PGPTVRAGEN VTLSCSSQSS FDIYHLSREG EAHELRLPAV PSINGTFQAD FPLGPATHGE TYRCFGSFHG SPYEWSDPSD PLPVSVTGNP SSSWPSPTEP SFKTGIARHL H; Positive Samples: HeLa, SKOV3, PC-12, Mouse uterus, Mouse kidney; Cellular Location: Cell membrane, Single-pass type I membrane protein

CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.

Specifications

• Antigen: KIR2DL4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KIR2DL4
• Gene Alias: CD158 antigen-like family member D, CD158D, G9P, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4, killer cell immunoglobulin-like receptor 2DL4, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4, killer cell inhibitory receptor 103AS, killer Ig receptor, killer-cell immunoglobulin-like receptor, killer-cell immunoglobulin-like receptor 2DL4, KIR, KIR103, KIR103AS, KIR-103AS, KIR2DL4, KIR-2DL4, MHC class I NK cell receptor KIR103AS, natural killer cell inhibitory receptor, natural killer cell receptor, NK cell receptor
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3805
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.1 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
• Gene Accession No.: Q99706
• Gene Symbols: KIR2DL4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-242 of human KIR2DL4 (NP_0022465)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG