Invitrogen™ KIR2DS2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114507

Catalog No. PIPA5114507

Description

Positive controls that may be used include: HEK293 Cell Lysate, HEK293 Cell Slide.

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Specifications

• Antigen: KIR2DS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KIR2DS2
• Gene Alias: 1060P11.9.2; 183ActI; CD158 antigen-like family member J; CD158b; CD158J; cl-49; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2; killer cell immunoglobulin-like receptor 2DS2; killer cell immunoglobulin-like receptor KIR2DS2; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2; killer-cell Ig-like receptor; killer-cell immunoglobulin-like receptor two domains short tail 2 protein; KIR2DS2; KIR-2DS2; MHC class I NK cell receptor; na; natural killer associated transcript 5; natural killer cell inhibitory receptor; natural killer cell receptor; Natural killer-associated transcript 5; NK receptor 183 ActI; NKAT5; NKAT-5; p58 killer cell inhibitory receptor KIR-K7a; p58 natural killer cell receptor clone CL-49; p58 NK receptor CL-49
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100132285
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P43631
• Gene Symbols: KIR2DS2
• Immunogen: KIR2DS2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KIR2DS2. The immunogen is located within the last 50 amino acids of KIR2DS2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG