Invitrogen™ KIR2DS3 Polyclonal Antibody

Catalog No.	Quantity
PIPA525667	400 μL

Catalog No. PIPA525667 Supplier Invitrogen™ Supplier No. PA525667

Description

Rabbit Polyclonal Antibody

KIR2DS3 Polyclonal Antibody for Western Blot, IHC (P), Flow

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Specifications

• Antigen: KIR2DS3
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: KIR2DS3
• Gene Accession No.: Q14952
• Gene Alias: killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3; killer cell immunoglobulin-like receptor 2DS3; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3; KIR2DS3; MHC class I NK cell receptor; natural killer cell inhibitory receptor; natural killer-associated transcript 7; NKAT7; NKAT-7
• Gene Symbols: KIR2DS3
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide between 268-295 amino acids from the C-terminal region of human KIR2DS3.
• Purification Method: Antigen Affinity Chromatography, Protein A
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3808
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov