Invitrogen™ KIR2DS5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103910

Catalog No. PIPA5103910

Description

Antibody detects endogenous levels of total KIR2DS5.

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Specifications

• Antigen: KIR2DS5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KIR2DS5
• Gene Alias: CD158 antigen-like family member G; CD158g; killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5; killer cell immunoglobulin-like receptor 2DS5; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5; KIR2DS5; MHC class I NK cell receptor; natural killer cell inhibitory receptor; natural killer cell receptor; natural killer-associated transcript 9; NKAT9; NKAT-9
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3810
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q14953
• Gene Symbols: KIR2DS5
• Immunogen: A synthesized peptide derived from human KIR2DS5(Accession Q14953), corresponding to amino acid residues R170-V220.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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