Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA553594

Invitrogen™ Kir3.4 (KCNJ5) Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA553594
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA553594 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA553594 Supplier Invitrogen™ Supplier No. PA553594
Only null left
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Immunogen sequence: VTPWDPKKIP KQARDYVPIA TDRTRLLAEG KKPRQRYMEK SGKCNVHHGN VQETY Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 89%.

G protein-coupled inwardly rectifying potassium channels (Kir3.1 through Kir3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, Kir3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbg subunits from G protein heterotrimers bind to and regulate Kir3 channel activity. Gb3- and Gb4-containing Gbg dimers bind directly to cytoplasmic domains of Kir3 proteins and increase the K+ current while Gb5-containing Gbg dimers inhibit Kir3 K+ current. Kir3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates Kir3 tyrosine residues, effectively inactivating the Kir3 channels.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kir3.4 (KCNJ5)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene KCNJ5
Gene Accession No. P48544
Gene Alias cardiac ATP-sensitive potassium channel; cardiac inward rectifier; CIR; G protein-activated inward rectifier potassium channel 4; GIRK4; GIRK-4; Heart KATP channel; inward rectifier K(+) channel Kir3.4; inward rectifier K+ channel KIR3.4; IRK4; IRK-4; KATP1; KATP-1; KCNJ5; Kir3.4; LQT13; Potassium channel, inwardly rectifying subfamily J member 5; potassium channel, inwardly rectifying subfamily J, member 5; potassium inwardly-rectifying channel, subfamily J, member 5; potassium voltage-gated channel subfamily J member 5
Gene Symbols KCNJ5
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human KCNJ5. Recombinant protein control fragment (Product #RP-90943).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3762
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.