Invitrogen™ KIR3DL2 Polyclonal Antibody

Catalog No.	Quantity
PIPA534816	100 μL

Catalog No. PIPA534816 Supplier Invitrogen™ Supplier No. PA534816

Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, H1299, HeLa, Molt-4, Raji. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals.

Specifications

• Antigen: KIR3DL2
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.61 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene: Kir3dl2
• Gene Accession No.: P43630
• Gene Alias: 3DL2; CD158 antigen-like family member K; CD158K; killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2; killer cell immunoglobulin-like receptor 3DL2; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2; killer Ig receptor; killer immunoglobulin-like receptor-like 2; killer-cell immunoglobulin-like receptor; killer-cell immunoglobulin-like receptor 3DL2; KIR antigen 3DL2; KIR3DL2; KIR-3DL2; Kirl2; KIR-like receptor 2; LOC727787; MHC class I NK cell receptor; natural killer cell receptor; natural killer-associated transcript 4; NKAT4; NKAT-4; NKAT4B; p140; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clone CL-5; p70 NK receptor CL-5
• Gene Symbols: Kir3dl2
• Host Species: Rabbit
• Immunogen: Synthetic peptide encompassing a sequence within the Extracellular domain of human LOC727787. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3812
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG