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Invitrogen™ KIR3DL2 Polyclonal Antibody
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Catalog No. PIPA545520
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100 μL
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PIPA545520 100 μL
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Catalog No. PIPA545520 Supplier Invitrogen™ Supplier No. PA545520
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Description

Rabbit Polyclonal Antibody

Peptide sequence: LFILLLFFLL YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ Sequence homology: Human: 100%.

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KIR3DL2
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene Kir3dl2
Gene Accession No. P43630
Gene Alias 3DL2; CD158 antigen-like family member K; CD158K; killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2; killer cell immunoglobulin-like receptor 3DL2; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2; killer Ig receptor; killer immunoglobulin-like receptor-like 2; killer-cell immunoglobulin-like receptor; killer-cell immunoglobulin-like receptor 3DL2; KIR antigen 3DL2; KIR3DL2; KIR-3DL2; Kirl2; KIR-like receptor 2; LOC727787; MHC class I NK cell receptor; natural killer cell receptor; natural killer-associated transcript 4; NKAT4; NKAT-4; NKAT4B; p140; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clone CL-5; p70 NK receptor CL-5
Gene Symbols Kir3dl2
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal of human KIR3DL2 (aa 351-400).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3812
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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