Kir6.2 (KCNJ11) Polyclonal Antibody, Invitrogen™

Guinea Pig Polyclonal Antibody

Supplier:  Thermo Scientific PA5111821

Catalog No. PIPA5111821

Description

Reconstitute antibody with 50 μL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Peptide sequence is: (C)SVAVAKA KPKFSIS Homology: Mouseamino acid residues identical; human - 12/14 amino acid residues identical.

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium By similarity. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Specifications

• Antigen: Kir6.2 (KCNJ11)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kcnj11
• Gene Alias: AI842722; ATP-sensitive inward rectifier potassium channel 11; AW491124; BIR; HHF2; IKATP; Inward rectifier K(+) channel Kir6.2; IRK11; KATP; KATP channel; Kcnj11; Kir6.2; mBIR; MGC133230; MODY13; PHHI; Potassium channel, inwardly rectifying subfamily J member 11; TNDM3
• Host Species: Guinea Pig
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16514, 3767, 83535
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P70673, Q14654, Q61743
• Gene Symbols: Kcnj11
• Immunogen: Peptide corresponding to amino acid residues 372-385 of rat Kir6.2 (intracellular, C-terminus)
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG