KIT Monoclonal Antibody (OTI2C1D5), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA801043

Catalog No. 50-167-8664

Description

c-Kit, also known as mast/stem cell growth factor receptor (SCFR) or CD117, is a trans membrane type III tyrosine kinase receptor encoded by the c-Kit proto-oncogene, located on chromosome 4 in humans. It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintece and gametogenesis.

Specifications

• Antigen: KIT
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P10721
• Gene Symbols: KIT
• Immunogen: Human recombit protein fragment corresponding to amino acids 546-976 of human KIT produced in SF9 cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2C1D5
• Conjugate: Unconjugated
• Gene: KIT
• Gene Alias: C-Kit, CD117, PBT, SCFR
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3815
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid