KIT Mouse anti-Human, Clone: OTI1E2, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF801037

Catalog No. 50-166-5423

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

c-Kit, also known as mast/stem cell growth factor receptor (SCFR) or CD117, is a trans membrane type III tyrosine kinase receptor encoded by the c-Kit proto-oncogene, located on chromosome 4 in humans. It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintece and gametogenesis.

Specifications

• Antigen: KIT
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: KIT
• Gene Alias: C-Kit, CD117, PBT, SCFR
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3815
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1E2
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P10721
• Gene Symbols: KIT
• Immunogen: Human recombit protein fragment corresponding to amino acids 546-976 of human KIT produced in SF9 cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1