KIT Mouse anti-Human, Clone: OTI1E2, liquid, TrueMAB™

Catalog No.	Quantity
50-167-7289	100 μg

Catalog No. 50-167-7289 Supplier OriGene Supplier No. TA600223

Description

Mouse Monoclonal Antibody

c-Kit, also known as mast/stem cell growth factor receptor (SCFR) or CD117, is a trans membrane type III tyrosine kinase receptor encoded by the c-Kit proto-oncogene, located on chromosome 4 in humans. It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintece and gametogenesis.

Specifications

• Antigen: KIT
• Applications: Immunoassay
• Classification: Monoclonal
• Clone: OTI1E2
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with <5% trehalose and 0.05% sodium azide
• Gene: KIT
• Gene Accession No.: P10721
• Gene Alias: C-Kit, CD117, PBT, SCFR
• Gene Symbols: KIT
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human KIT produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3815
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1