Invitrogen™ KLDC3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556358

Catalog No. PIPA556358

Description

Immunogen sequence: FHSATMLGSH MYVFGGRADR FGPFHSNNEI YCNRIRVFDT RTEAWLDCPP TPVLPEGRRS HSAFGYNGEL YIFGGYNARL NRHFHDLWKF NPVSF Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. The Kelch domain-containing protein 3 (KLHDC3), also designated PEAS, contains 5 Kelch repeats and may be involved in meiotic recombination process. The gene encoding KLHDC3 maps to chromosome 6, which contains around 1, 200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. KLHDC3 protein is mainly expressed in cytoplasm, also found in meiotic chromatin.

Specifications

• Antigen: KLDC3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KLHDC3
• Gene Alias: 1300011D16Rik; dJ20C7.3; kelch domain containing 3; kelch domain-containing protein 3; KLHDC3; Peas; Protein Peas; RP1-20C7.3; testis intracellular mediator protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116138
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BQ90
• Gene Symbols: KLHDC3
• Immunogen: Recombinant protein corresponding to Human KLDC3. Recombinant protein control fragment (Product #RP-94799).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG