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Invitrogen™ KLF10 Polyclonal Antibody
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Catalog No. PIPA589053
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100 μL
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PIPA589053 100 μL
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Catalog No. PIPA589053 Supplier Invitrogen™ Supplier No. PA589053
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MKAASILNYQ NNSFRRRTHL NVEAARKNIP CAAVSPNRSK CERNTVADVD EKASAALYDF SVPSSETVIC RSQPAPVSPQ QKSVLVSPPA VSAGGVPPMP VICQMVPLPA NNPVVTTVVP STPPSQPPAV CPPVVFMGTQ VPKGAVMFVV PQPVVQSSKP PVVSPNGTRL SPIAPAPGFS PSAAKVTPQI DSSRIRSHIC SHPGC; Positive Samples: Mouse kidney, Mouse skeletal muscle, Rat kidney; Cellular Location: Nucleus.

KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth. It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta thus playing a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth. KLF10 is involved in inducing and promoting apoptosis through the mitochondrial apoptotic pathway and may inhibit Smad7 expression in bronchial epithelial cells. Ubiquitous expression of KLF10 is seen in most of the tissues. Reports suggest that it may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers. Over expression of KLF10 may be associated with renal clear cell carcinoma and other tumors. KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KLF10
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.15 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene KLF10
Gene Accession No. O08876, O89091
Gene Alias AI115143; Cpg20; early growth response-alpha; EGR[a]; EGRA; Egral; EGR-alpha; Gdnfif; GDNF-inducible factor; Klf10; Krueppel-like factor 10; Kruppel like factor 10; Kruppel-like factor 10; mGIF; TGFB inducible early growth response; TGFB inducible early growth response 1; TGFB-inducible early growth response protein 1; Tieg; TIEG1; TIEG-1; transcription factor GIF; Transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor homolog CPG20; zinc finger transcription factor TIEG
Gene Symbols KLF10
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 161-365 of human KLF10 (NP_0010274531).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21847, 81813
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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