Invitrogen™ KLF10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589053

Catalog No. PIPA589053

Description

Immunogen sequence: MKAASILNYQ NNSFRRRTHL NVEAARKNIP CAAVSPNRSK CERNTVADVD EKASAALYDF SVPSSETVIC RSQPAPVSPQ QKSVLVSPPA VSAGGVPPMP VICQMVPLPA NNPVVTTVVP STPPSQPPAV CPPVVFMGTQ VPKGAVMFVV PQPVVQSSKP PVVSPNGTRL SPIAPAPGFS PSAAKVTPQI DSSRIRSHIC SHPGC; Positive Samples: Mouse kidney, Mouse skeletal muscle, Rat kidney; Cellular Location: Nucleus.

KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth. It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta thus playing a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth. KLF10 is involved in inducing and promoting apoptosis through the mitochondrial apoptotic pathway and may inhibit Smad7 expression in bronchial epithelial cells. Ubiquitous expression of KLF10 is seen in most of the tissues. Reports suggest that it may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers. Over expression of KLF10 may be associated with renal clear cell carcinoma and other tumors. KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.

Specifications

• Antigen: KLF10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KLF10
• Gene Alias: AI115143; Cpg20; early growth response-alpha; EGR[a]; EGRA; Egral; EGR-alpha; Gdnfif; GDNF-inducible factor; Klf10; Krueppel-like factor 10; Kruppel like factor 10; Kruppel-like factor 10; mGIF; TGFB inducible early growth response; TGFB inducible early growth response 1; TGFB-inducible early growth response protein 1; Tieg; TIEG1; TIEG-1; transcription factor GIF; Transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor homolog CPG20; zinc finger transcription factor TIEG
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21847, 81813
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.15 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O08876, O89091
• Gene Symbols: KLF10
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 161-365 of human KLF10 (NP_0010274531).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG