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KLF15 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550232

Catalog No. PA550232


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Description

Description

The antibody detects endogenous levels of total KLF15 protein.

KLF15 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. A transcriptional activator, KLF15 binds to the GA element of the CLCNKA promoter and may help to regulate the strict tissue and nephron segment-specific expression of CLCNKA and CLCNKB channel genes. It plays an essential role in adipogenesis in cells through its regulation of PPARG expression. Reports suggest that KLF15 is an inhibitor of cardiac hypertrophy and functions in a pathway, regulating the cardiac response to hemodynamic stress, and regulates mitochondrial acetyl-CoA synthase expression in skeletal muscle. KLF15 may also act as a transcriptional repressor of the rhodopsin and IRBP promoters in the retina, and is a possible participant in repression of photoreceptor-specific gene expression in nonphotoreceptor cells. It is highly expressed in liver, followed by heart, skeletal muscle, and kidney but not expressed in bone marrow or lymphoid tissues.
Specifications

Specifications

KLF15
Polyclonal
Unconjugated
KLF15
Liquid
KLF15
Fusion protein corresponding to residues near the N terminal of human Kruppel-like factor 15
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
1.3 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9UIH9
DKFZp779M1320, KKLF
Rabbit
IgG
100 μL
-20°C
Primary
28999
Documents
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