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Invitrogen™ KLHL26 Polyclonal Antibody

Catalog No. PIPA535910
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100 μL
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PIPA535910 100 μL
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Catalog No. PIPA535910 Supplier Invitrogen™ Supplier No. PA535910
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Description

Rabbit Polyclonal Antibody

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. Predicted reactivity: Human (99%), Mouse (84%), Rat (84%), Zebrafish (80%), Rhesus Monkey (99%).

KLHL26, part of the Kelch-like family member 26, is a protein-coding gene located on chromosome 19. It has been associated with various cellular functions due to its structural components, particularly the BTB/POZ domain at the N-terminus which spans about 115 amino acids. This domain plays crucial roles in forming E3 ubiquitin ligases by facilitating interactions with Cullin3 and enabling KLHL protein homodimerization. The significance of KLHL26 extends to its potential involvement in familial genetic conditions, as evidenced by the identification of a novel damaging variant, which was validated through Sanger sequencing in affected family members. Moreover, the Kelch motif within the KLHL proteins underlines their diverse roles in cellular morphology, gene expression regulation, and interaction with extracellular entities, including possible implications in actin binding and virus interactions post-infection.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KLHL26
Applications Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene KLHL26
Gene Accession No. Q53HC5
Gene Alias C630013N10Rik; kelch like family member 26; kelch-like 26; kelch-like family member 26; kelch-like protein 26; KLHL26; Klkl26; RGD1312034
Gene Symbols KLHL26
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human KLHL26. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55295
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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