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Invitrogen™ Klotho Polyclonal Antibody
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Catalog No. PA129899
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25 μg
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Catalog No. Quantity
PA129899 25 μg
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Catalog No. PA129899 Supplier Invitrogen™ Supplier No. PA129899
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Description

Rabbit Polyclonal Antibody

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Klotho
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris HCl with 0.2% BSA and 0.05% sodium azide; pH 7.5
Gene KL
Gene Accession No. O35082
Gene Alias alpha-kl; HFTC3; Kl; Klotho; Klotho peptide; secreted form of Klotho protein
Gene Symbols KL
Host Species Rabbit
Immunogen Synthetic peptide of 17 amino acids (Mouse) (C terminal).
Purification Method Antigen affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16591
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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