Invitrogen™ Klotho Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA129899

Catalog No. PA129899

Description

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.

Specifications

• Antigen: Klotho
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KL
• Gene Alias: alpha-kl; HFTC3; Kl; Klotho; Klotho peptide; secreted form of Klotho protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16591
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris HCl with 0.2% BSA and 0.05% sodium azide; pH 7.5
• Gene Accession No.: O35082
• Gene Symbols: KL
• Immunogen: Synthetic peptide of 17 amino acids (Mouse) (C terminal).
• Quantity: 25 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG