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PeproTech Klotho Polyclonal Antibody, PeproTech®, Invitrogen™

Catalog No. 500P2961MG
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500P2961MG 1 mg
500P29650UG 50 μg
500P296100 100 μg
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Catalog No. 500P2961MG Supplier PeproTech Supplier No. 500P2961MG
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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGGWQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD VASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGLRYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DHFRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSPRL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPRRMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDFT ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQLLSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKMLLPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYH. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human Klotho. Anti-Human Klotho-specific antibody was purified by affinity chromatography employing an immobilized Human Klotho matrix. Sandwich ELISA: To detect Human Klotho by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human Klotho (500-P296Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human Klotho. Western Blot: To detect hKlotho by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hKlotho is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Klotho
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene KL
Gene Accession No. Q9UEF7
Gene Alias alpha-kl; HFTC3; Kl; Klotho; Klotho peptide; secreted form of Klotho protein
Gene Symbols KL
Host Species Rabbit
Immunogen E.coli-derived Recombinant Human Klotho.
Purification Method Antigen affinity chromatography
Quantity 1 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9365
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
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