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Klotho Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985015
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100 μL
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Catalog No. Quantity
50-198-5015 100 μL
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Catalog No. 50-198-5015 Supplier Bioss Supplier No. BS2925R
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Description

Rabbit Polyclonal Antibody

KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.

Specifications

Antigen Klotho
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene KL
Gene Accession No. Q9UEF7
Gene Alias alpha-kl; BOS_12399; HFTC3; KL; Klotho; Klotho peptide; Klotho-like; LOC100356074; secreted form of Klotho protein
Gene Symbols KL
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Klotho.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9365
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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