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Invitrogen™ KMT2D Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA549581
Description
KMT2D Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)
KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription. KMT2D is involved in chromatin organization, chormatin silencig, oocyte growth, oogenesis, and a positive regulation of cell proliferation. Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1) which results in congential mental retardation syndrome.
Specifications
KMT2D | |
Polyclonal | |
Unconjugated | |
KMT2D | |
AAD10; ALL1-related protein; ALR; CAGL114; Histone-lysine N-methyltransferase 2D; histone-lysine N-methyltransferase MLL2; KABUK1; Kabuki make-up syndrome; Kabuki mental retardation syndrome; KMS; KMT2D; lysine (K)-specific methyltransferase 2D; lysine methyltransferase 2D; lysine N-methyltransferase 2D; MLL2; MLL4; myeloid/lymphoid or mixed-lineage leukemia 2; Myeloid/lymphoid or mixed-lineage leukemia protein 2; TNRC21; trinucleotide repeat containing 21 | |
Rabbit | |
Antigen Affinity Chromatography, Protein A | |
RUO | |
8085 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
O14686 | |
KMT2D | |
KLH conjugated synthetic peptide between 4980-5009 amino acids from the C-terminal region of human MLL2. | |
400 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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