Invitrogen™ KMT2D Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557490

Catalog No. PIPA557490

Description

Immunogen sequence: AQLADTLFSK GLGPWDPPDN LAETQKPEQS SLVPGHLDQV NGQVVPEASQ LSIKQEPREE PCALGAQSVK REANGEPIGA PGTSNHLLLA GPRSEAGHLL LQKLLRAKNV QLSTGRGSEG LRAEINGHI Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 84%.

KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription. KMT2D is involved in chromatin organization, chormatin silencig, oocyte growth, oogenesis, and a positive regulation of cell proliferation. Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1) which results in congential mental retardation syndrome.

Specifications

• Antigen: KMT2D
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KMT2D
• Gene Alias: AAD10; ALL1-related protein; ALR; CAGL114; Histone-lysine N-methyltransferase 2D; histone-lysine N-methyltransferase MLL2; KABUK1; Kabuki make-up syndrome; Kabuki mental retardation syndrome; KMS; KMT2D; lysine (K)-specific methyltransferase 2D; lysine methyltransferase 2D; lysine N-methyltransferase 2D; MLL2; MLL4; myeloid/lymphoid or mixed-lineage leukemia 2; Myeloid/lymphoid or mixed-lineage leukemia protein 2; TNRC21; trinucleotide repeat containing 21
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8085
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O14686
• Gene Symbols: KMT2D
• Immunogen: Recombinant protein corresponding to Human KMT2D. Recombinant protein control fragment (Product #RP-102441).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG