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Invitrogen™ KPNA2 Monoclonal Antibody (2G7)
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Catalog No. PIMA517016
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50 μL
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PIMA517016 50 μL
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Catalog No. PIMA517016 Supplier Invitrogen™ Supplier No. MA517016
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Description

Rat Monoclonal Antibody

MA5-17016 reacts with karyopherin 2 in human samples. MA5-17016 has been successfully used in Western blot applications. The MA5-17016 immunogen is amino acids 116-515 produced in P3-x63Ag.8.653 cells.

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1, which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in VJ recombination.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KPNA2
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2G7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene KPNA2
Gene Accession No. P52292, P52293
Gene Alias 2410044B12Rik; IMA2; importin; importin alpha 2; importin alpha P1; Importin subunit alpha-1; importin subunit alpha-2; importin-alpha-P1; IPOA 1; IPOA1; IPOA1 QIP2; karyopherin (importin) alpha 2; Karyopherin A2; karyopherin alpha 2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); karyopherin subunit alpha 2; karyopherin subunit alpha-2; Kpna2; m-importin-alpha-P1; nuclear import protein; pendulin; Pore targeting complex 58 kDa subunit; PTAC58; QIP2; RAG cohort 1; RAG cohort protein 1; RCH 1; RCH1; SRP 1; SRP1; SRP1 alpha; SRP1alpha; SRP1-alpha
Gene Symbols KPNA2
Host Species Rat
Immunogen Synthetic peptide, corresponding to amino acids 116-515 of Human KPNA2.
Purification Method Protein G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16647, 3838
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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