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KPNA2 Mouse anti-Human, Mouse, Clone:1E8B7, Abnova™

Catalog No. 89333602 Shop All Abnova Corporation Products
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Catalog No. Quantity
89-333-602 100 μg
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Catalog No. 89-333-602 Supplier Abnova Corporation Supplier No. MAB17179
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Description

Mouse monoclonal antibody raised against recombinant human KPNA2.

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq]

Specifications

Antigen KPNA2
Applications ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 1E8B7
Conjugate Unconjugated
Description karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Dilution ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry (1:200-1:1000)
Immunocytochemistry (1:200-1:1000)
Flow Cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.
Formulation In PBS (0.05% sodium azide)
Gene KPNA2
Gene Alias IPOA1, QIP2, RCH1, SRP1alpha
Host Species Mouse
Immunogen Recombinant protein corresponding to amino acid 1-530 of human KPNA2 from E. coli.
Quantity 100 μg
Gene ID (Entrez) 3838
Target Species Human, Mouse
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Product Type Antibody
Form Liquid
Isotype IgG1
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