Invitrogen™ KPNA2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595724

Catalog No. PIPA595724

Description

Immunogen sequence: MSTNENANTP AARLHRFKNK GKDSTEMRRR RIEVNVELRK AKKDDQMLKR RNVSSFPDDA TSPLQENRNN QGTVNWSVDD IVKGINSSNV ENQLQATQAA RKLLSREKQP PIDNIIRAGL IPKFVSFLGR TDCSPIQFES AWALTNIASG TSEQTKAVVD GGAIPAFISL LASPHAHISE QAVWALGNIA GDGSVFRDLV IKYGAVDPLL ALLAVPDMSS LACGYLRNLT WTLSNLCRNK NPAPPIDAVE QILPTLVRLL HHDDPEVLAD TCWAISYLTD GPNERIGMVV; Positive Samples: MCF7, PC-3, U-251MG, Mouse testis; Cellular Location: Cytoplasm, Nucleus.

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1, which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in VJ recombination.

Specifications

• Antigen: KPNA2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KPNA2
• Gene Alias: 2410044B12Rik; IMA2; importin; importin alpha 2; importin alpha P1; Importin subunit alpha-1; importin subunit alpha-2; importin-alpha-P1; IPOA 1; IPOA1; IPOA1 QIP2; karyopherin (importin) alpha 2; Karyopherin A2; karyopherin alpha 2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); karyopherin subunit alpha 2; karyopherin subunit alpha-2; Kpna2; m-importin-alpha-P1; nuclear import protein; pendulin; Pore targeting complex 58 kDa subunit; PTAC58; QIP2; RAG cohort 1; RAG cohort protein 1; RCH 1; RCH1; SRP 1; SRP1; SRP1 alpha; SRP1alpha; SRP1-alpha
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16647, 3838
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunoprecipitation, Western Blot
• Concentration: 0.85 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P52292, P52293
• Gene Symbols: KPNA2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human KPNA2 (NP_0022571).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG