Invitrogen™ KPNA6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597906

Catalog No. PIPA597906

Description

KPNA6 Polyclonal Antibody for Western Blot, IHC (P), ELISA

Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.

Specifications

• Antigen: KPNA6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KPNA6
• Gene Alias: FLJ11249; importin alpha 7 subunit; importin alpha-S2; Importin subunit alpha-7; importin-alpha-S2; IPOA7; karyopherin (importin) alpha 5; karyopherin (importin) alpha 6; karyopherin alpha 6; karyopherin alpha 6 (importin alpha 7); karyopherin subunit alpha 6; karyopherin subunit alpha-6; Kpna5; Kpna6; KPNA7; MGC17918; NPI-2; RP4-622L5.1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23633
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O60684
• Gene Symbols: KPNA6
• Immunogen: Recombinant Human Importin subunit alpha-7 protein (277-536AA).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov