KPNB1 Mouse anti-Human, Mouse, Rat, Clone: OTI9D6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF811714

Catalog No. 50-167-0799

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

Specifications

• Antigen: KPNB1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: KPNB1
• Gene Alias: IMB1, IPO1, IPOB, Impnb, NTF97
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16211, 24917, 3837
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI9D6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P52296, P70168, Q14974
• Gene Symbols: Kpnb1
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-200 of human KPNB1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a