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Invitrogen™ KPNB1 Polyclonal Antibody
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Catalog No. PIPA578034
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100 μL
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PIPA578034 100 μL
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Catalog No. PIPA578034 Supplier Invitrogen™ Supplier No. PA578034
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Description

Rabbit Polyclonal Antibody

Positive Control: 293T, A431, HeLa, HepG2 Predicted Reactivity: Mouse (99%), Rat (98%), Zebrafish (93%), Xenopus laevis (91%), Chimpanzee (100%), Bovine (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KPNB1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.32 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene KPNB1
Gene Accession No. P70168, Q14974
Gene Alias AA409963; HGNC:6400; IMB1; Impnb; importin 1; importin 90; importin beta; importin beta-1 subunit; importin subunit beta-1; Importin-90; IPO1; IPOB; KapB1; karyopherin (importin) beta 1; karyopherin beta 1; karyopherin subunit beta 1; karyopherin subunit beta-1; karyopherin,beta 1; Kpnb1; MGC2155; MGC2156; MGC2157; NTF97; Nuclear factor p97; pore targeting complex 97 kDa subunit; PTAC97; SCG
Gene Symbols KPNB1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the N-terminus region of Human Importin beta 1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16211, 3837
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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