Tocris™ KRCA 0008

Potent Ack1 and ALK dual inhibitor; orally bioavailable

Manufacturer: Tocris™ 5098/10

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Catalog No. 50-981-0R

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For Research Use Only


    Product Type KRCA 0008
    Inhibitors KRCA 0008
    Purity >99
    Molecular Weight 609.12
    Quantity 10mg

    Potent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50 values are 4 and 12nM respectively). Inhibits lung cancer H3122 cell proliferation (IC50 = 80nM). Attenuates H3122 cell xenograft tumor growth in mice. Orally bioavailable.

    • Chemical Name: 1,1'-[(5-Chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bisethanone
    • Formula: C30H37ClN8O4
    • CAS Number: 1472795-20-2
    • Solubility: Soluble to 100mM in 1eq. HCl and to 100mM in DMSO and to 100mM in ethanol
    • Purity: >99

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