Tocris KRCA 0008
Potent Ack1 and ALK dual inhibitor; orally bioavailable
Manufacturer: Tocris 5098/10
DescriptionPotent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50 values are 4 and 12nM respectively). Inhibits lung cancer H3122 cell proliferation (IC50 = 80nM). Attenuates H3122 cell xenograft tumor growth in mice. Orally bioavailable.
- Chemical Name: 1,1'-[(5-Chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bisethanone
- Formula: C30H37ClN8O4
- CAS Number: 1472795-20-2
- Solubility: Soluble to 100mM in 1eq. HCl and to 100mM in DMSO and to 100mM in ethanol
- Purity: >99
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