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Invitrogen™ KREMEN2 Polyclonal Antibody
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Catalog No. 381700
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100 μg
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Catalog No. Quantity
38-170-0 100 μg
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Catalog No. 38-170-0 Supplier Invitrogen™ Supplier No. 381700
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Description

Rabbit Polyclonal Antibody

KREMEN2 Polyclonal Antibody for Western Blot

Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KREMEN2
Applications Western Blot
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene KREMEN2
Gene Accession No. Q8K1S7
Gene Alias 2900054E04Rik; Dickkopf receptor 2; kremen protein 2; KREMEN2; kringle containing transmembrane protein 2; kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose; Krm2
Gene Symbols KREMEN2
Host Species Rabbit
Immunogen Synthetic peptide derived from the internal region of human, mouse and rat Kremen2 proteins.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 73016
Target Species Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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