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KREMEN2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984025
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50-198-4025 100 μL
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Catalog No. 50-198-4025 Supplier Bioss Supplier No. BS16813R
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Description

Rabbit Polyclonal Antibody

Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.

Specifications

Antigen KREMEN2
Applications Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene KREMEN2
Gene Accession No. Q8NCW0
Gene Alias 2900054E04Rik; Dickkopf receptor 2; Kremen protein 2; Kremen2; kringle containing transmembrane protein 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose; KRM2
Gene Symbols KREMEN2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human KREMEN2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79412
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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