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Invitrogen™ KRIT1 Polyclonal Antibody
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Catalog No. PIPA562020
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100 μL
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PIPA562020 100 μL
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Catalog No. PIPA562020 Supplier Invitrogen™ Supplier No. PA562020
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SLQLKPYHKP LQHVRDWPEI LAELTNLDPQ RETPQLFLRR DVRLPLEVEK QIEDPLAILI LFDEARYNLL KGFYTAPDAK LITLASLLLQ IVYGNYESKK HKQGFLNEEN LKSIV Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 97%.

This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KRIT1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene KRIT1
Gene Accession No. O00522
Gene Alias 2010007K12Rik; A630036P20Rik; AA432855; AI450393; AI643869; ankyrin repeat-containing protein Krit1; BB155247; BB235701; CAM; Ccm1; Cerebral cavernous malformations 1 protein; cerebral cavernous malformations 1 protein homolog; Krev interaction trapped 1; krev interaction trapped protein 1; KRIT1; KRIT1, ankyrin repeat containing; RGD1305929
Gene Symbols KRIT1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human KRIT1. Recombinant protein control fragment (Product #RP-92586).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 889
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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