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Invitrogen™ Cytokeratin 14/16 Polyclonal Antibody
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Catalog No. PIPA599310
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PIPA599310 100 μL
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Catalog No. PIPA599310 Supplier Invitrogen™ Supplier No. PA599310
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Cytokeratin 14/16.

In Bowen's disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cytokeratin 14/16
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Krt16
Gene Accession No. P02533, P08779, Q61781, Q6IFV1, Q9Z2K1
Gene Alias AI324768; AI626930; CK 14; CK 16; CK14; CK-14; CK16; CK-16; cytokeratin 14; cytokeratin 16; Cytokeratin14; cytokeratin-14; Cytokeratin16; Cytokeratin-16; EBS3; EBS4; epidermolysis bullosa simplex, Dowling-Meara, Koebner; FNEPPK; focal non-epidermolytic palmoplantar keratoderma; K14; K16; K1CP; Ka14; Ka16; keratin 14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 16; keratin 16, type I; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 16; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 16; keratin-14; Keratin-16; Krt-1.14; Krt1-14; Krt1-16; Krt14; KRT16; KRT16A; NEPPK; NFJ; PC1; Type I keratin Ka14; type I keratin KA16
Gene Symbols KRT14, Krt16
Host Species Rabbit
Immunogen A synthesized peptide derived from human KRT14(Accession P02533), corresponding to amino acid residues M1-A36.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16664, 16666, 287701, 303530, 3861, 3868
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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