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KRT18 Mouse anti-Human, Clone: OTI3D1, lyophilized, TrueMAB™
SDP

Catalog No. 501668153
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100 μg
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Catalog No. Quantity
50-166-8153 100 μg
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Catalog No. 50-166-8153 Supplier OriGene Supplier No. CF807190
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18. Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial maligcies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Specifications

Antigen KRT18
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI3D1
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene KRT18
Gene Accession No. P05783
Gene Alias CK-18, CYK18, K18
Gene Symbols KRT18
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 69-372 of human KRT18 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3875
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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