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Invitrogen™ Krt222 Polyclonal Antibody
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Catalog No. PIPA562986
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100 μL
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PIPA562986 100 μL
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Catalog No. PIPA562986 Supplier Invitrogen™ Supplier No. PA562986
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YYGCIQGGKK DKKPTTSRVG FVLPSAIINE ISFTTKVPQK YENENVETVT KQAILNGSIV KESTEAHGTI Q Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 75%.

KRT222, also known as KRT222P. KRT222 is a 295 amino acid protein belonging to the intermediate filament family. The gene encoding KRT222P has been listed as a pseudogene, however it has not been established that the protein is not translated, and is therefore treated as a protein coding gene. Existing as two alternatively spliced isoforms, the gene encoding KRT222P maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Krt222
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Krt222
Gene Accession No. Q8N1A0
Gene Alias 6330509G02Rik; KA21; keratin 222; keratin 222 pseudogene; keratin 222, type II; keratin-222; Keratin-222 pseudogene; keratin-like protein KRT222; Krt222; KRT222P
Gene Symbols Krt222
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human Krt222. Recombinant protein control fragment (Product #RP-104496).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 125113
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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