Invitrogen™ Krt222 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562986

Catalog No. PIPA562986

Description

Immunogen sequence: YYGCIQGGKK DKKPTTSRVG FVLPSAIINE ISFTTKVPQK YENENVETVT KQAILNGSIV KESTEAHGTI Q Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 75%.

KRT222, also known as KRT222P. KRT222 is a 295 amino acid protein belonging to the intermediate filament family. The gene encoding KRT222P has been listed as a pseudogene, however it has not been established that the protein is not translated, and is therefore treated as a protein coding gene. Existing as two alternatively spliced isoforms, the gene encoding KRT222P maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Specifications

• Antigen: Krt222
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Krt222
• Gene Alias: 6330509G02Rik; KA21; keratin 222; keratin 222 pseudogene; keratin 222, type II; keratin-222; Keratin-222 pseudogene; keratin-like protein KRT222; Krt222; KRT222P
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 125113
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8N1A0
• Gene Symbols: Krt222
• Immunogen: Recombinant protein corresponding to Human Krt222. Recombinant protein control fragment (Product #RP-104496).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG