KSHV ORF45 Monoclonal Antibody (2D4A5), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA514769

Catalog No. PIMA514769

Description

MA5-14769 targets KSHV ORF45 in indirect ELISA, IHC and WB applications and shows reactivity with Virus samples. The MA5-14769 immunogen is purified recombinant fragment of KSHV ORF45 expressed in E. Coli.

Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions.

Specifications

• Antigen: KSHV ORF45
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.03% sodium azide
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry, Western Blot
• Clone: 2D4A5
• Conjugate: Unconjugated
• Gene Alias: Kaposi's Sarcoma Virus; Kaposi's sarcoma-associated herpesvirus
• Immunogen: Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG1