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Invitrogen™ KSHV ORF45 Monoclonal Antibody (2D4A5)
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Catalog No. PIMA514769
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100 μL
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Catalog No. Quantity
PIMA514769 100 μL
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Catalog No. PIMA514769 Supplier Invitrogen™ Supplier No. MA514769
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Description

Mouse Monoclonal Antibody

MA5-14769 targets KSHV ORF45 in indirect ELISA, IHC and WB applications and shows reactivity with Virus samples. The MA5-14769 immunogen is purified recombinant fragment of KSHV ORF45 expressed in E. Coli.

Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KSHV ORF45
Applications ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2D4A5
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene Alias Kaposi's Sarcoma Virus; Kaposi's sarcoma-associated herpesvirus
Host Species Mouse
Immunogen Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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