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Invitrogen™ KSR1 Polyclonal Antibody
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Catalog No. PIPA5120331
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PIPA5120331 100 μL
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Catalog No. PIPA5120331 Supplier Invitrogen™ Supplier No. PA5120331
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Description

Rabbit Polyclonal Antibody

Positive test controls include: U-251MG, HeLa, Jurkat, mouse brain, mouse spleen, mouse testis, mouse kidney, mouse lung, rat brain. The target is usually found in the following locations: Cytoplasm, Endoplasmic reticulum membrane, Membrane, Peripheral membrane protein. Immunogen sequence: SSPAPFPTSS NPSSATTPPN PSPGQRDSRF NFPAAYFIHH RQQFIFPVPS AGHCWKCLLI AESLKENAFN ISAFAHAAPL PEAADGTRLD DQPKADVLEA H.

Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen KSR1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.69 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene KSR1
Gene Accession No. Q61097, Q8IVT5
Gene Alias AW492498; B-KSR1; CAP kinase; D11Bhm183e; D11Bhm184e; hb; HB protein; kinase KSR1; Kinase suppressor of Ras 1; Ksr; KSR1; mKSR1; OTTHUMP00000162931; protein Hb; RSU2
Gene Symbols KSR1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 320-420 of human KSR1 (NP_055053.1).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16706, 360573, 8844
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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