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Invitrogen™ KSR2 Polyclonal Antibody
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Catalog No. PIPA575293
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100 μL
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Catalog No. Quantity
PIPA575293 100 μL
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Catalog No. PIPA575293 Supplier Invitrogen™ Supplier No. PA575293
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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

KSR2 serine/threonine kinase or kinase suppressor of Ras 2 specifically regulates the activity of MEKK3 and COT but not other members of the MAP3K family. KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans. Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KSR2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene KSR2
Gene Accession No. Q3UVC0, Q6VAB6
Gene Alias hKSR2; Kinase suppressor of Ras 2; ksr2; RGD1562674; testes-kinase suppressor of ras 2 isoform
Gene Symbols KSR2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 662-724 of Human Ksr2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 283455, 288691, 333050
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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